Café Scientifique Manchester
Cafe Scientifique is a place where, for the price of a cup of coffee or a glass of wine, anyone can come to explore the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context.
Cafe Scientifique is a forum for debating science issues, not a shop window for science. We are committed to promoting public engagement with science and to making science accountable.
When: 7.30pm on the last Thursday of every month
Where: The MadLab, 36-40 Edge Street, M4 1HN
|Date||28 July 2016|
|Title||Text Mining: Finding the needle in the haystack you didn't even know was there!|
|Speaker||Professor Sophia Ananiadou|
With the massive amount of knowledge recorded in unstructured textual form, we need automated methods that can extract and manage it. Text mining is a relatively new area of research used to extract automatically nuggets of information hidden in text and to present the distilled knowledge to users in a concise and meaningful manner. The National Centre for Text Mining (www.nactem.ac.uk, located at the School of Computer Science, The University of Manchester) has developed a number of text mining services to support a wide variety of users who are struggling to locate useful information from big textual data for their needs. Join this session with Professor Sophia Ananiadou and find out how computers can help us digest large amount of information!
Image from gatech.edu
|Date||29 September 2016|
|Title||Jet lag in tendons|
|Speaker||Professor Karl Kadler|
We are made aware of our circadian clock (or body clock) when we travel by airplane to another time zone; the brain thinks it’s back in Manchester and should be going to sleep but the body is somewhere else and is busy walking about. The jet lag we feel is because the circadian clock turns certain genes on and off in anticipation of day-night activities such as eating, walking, running, and sleeping. The clock in the brain is the master clock, and it is ‘reset’ in the morning when we see the rising sun. The brain clock then sends messages to the body to get ready to wake up. Prof Karl Kadler’s group at the University of Manchester has shown that there is a clock in tendons, which join muscles to bone. His research is showing that the ‘tendon clock’ maintains the health of tendons. However, as we age, the tendon clock is less effective and the communication between the brain clock and the tendon clock is ‘out of sync’. Do older people have permanent tendon jet lag? Does this explain why older people have aches and pains in their joints and tendons, and why they ‘stiffen up’ at certain times of the day? People over 40 years old are prone to tendon ruptures; is this because the tendon clock is running slow? In this session, we will look at the evidence and discuss how knowledge of body clocks might help us learn more about our bodies and improve our quality of life.
Picture shows the changes in gene expression in young tendon every 4 hours during 2 days. Green is when a gene is ‘on’ and red is when it is ‘off’.