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Café Scientifique

Café Scientifique Manchester

Cafe Scientifique is a place where, for the price of a cup of coffee or a glass of wine, anyone can come to explore the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context.

Cafe Scientifique is a forum for debating science issues, not a shop window for science. We are committed to promoting public engagement with science and to making science accountable.

When: 7.30pm on the last Thursday of every month

Where: The MadLab, 36-40 Edge Street, M4 1HN 

Date 29 September 2016
Title Jet lag in tendons
Speaker Professor Karl Kadler

We are made aware of our circadian clock (or body clock) when we travel by airplane to another time zone; the brain thinks it’s back in Manchester and should be going to sleep but the body is somewhere else and is busy walking about. The jet lag we feel is because the circadian clock turns certain genes on and off in anticipation of day-night activities such as eating, walking, running, and sleeping.  The clock in the brain is the master clock, and it is ‘reset’ in the morning when we see the rising sun.  The brain clock then sends messages to the body to get ready to wake up.  Prof Karl Kadler’s group at the University of Manchester has shown that there is a clock in tendons, which join muscles to bone.  His research is showing that the ‘tendon clock’ maintains the health of tendons.  However, as we age, the tendon clock is less effective and the communication between the brain clock and the tendon clock is ‘out of sync’.  Do older people have permanent tendon jet lag?  Does this explain why older people have aches and pains in their joints and tendons, and why they ‘stiffen up’ at certain times of the day?  People over 40 years old are prone to tendon ruptures; is this because the tendon clock is running slow? In this session, we will look at the evidence and discuss how knowledge of body clocks might help us learn more about our bodies and improve our quality of life. 


Picture shows the changes in gene expression in young tendon every 4 hours during 2 days. Green is when a gene is ‘on’ and red is when it is ‘off’.

Organisers: Bo YaoDeborah Talmi

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